RP-8-CPT-CAMPS
| 中文名称 | RP-8-CPT-CAMPS |
|---|---|
| 中文同义词 | |
| 英文名称 | 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt |
| 英文同义词 | 8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH;RP-8-CPT-CAMPS;RP-8-CPT-CAMPS SODIUM SALT;8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi;8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER;Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate];S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-but-2-enethioate;8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt |
| CAS号 | 129735-01-9 |
| 分子式 | C16H14ClN5NaO5PS2 |
| 分子量 | 509.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 129735-01-9.mol |
| 结构式 |  |
RP-8-CPT-CAMPS 性质
| 储存条件 | −20°C |
|---|---|
| 形态 | 固体 |
| 生物来源 | synthetic (organic) |
| InChIKey | AWXMSJRRXLCVMW-JVSRKQJHSA-M |
| SMILES | [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12 |
Rp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。
PKA
Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol.
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP.
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP.
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |