| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
inquiry@bocsci.com |
|
| | 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt Basic information |
| Product Name: | 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt | | Synonyms: | 8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH;RP-8-CPT-CAMPS;RP-8-CPT-CAMPS SODIUM SALT;8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi;8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER;Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate];S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-but-2-enethioate;8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt | | CAS: | 129735-01-9 | | MF: | C16H14ClN5NaO5PS2 | | MW: | 509.86 | | EINECS: | | | Product Categories: | | | Mol File: | 129735-01-9.mol |  |
| | 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt Chemical Properties |
| storage temp. | −20°C | | form | solid | | biological source | synthetic (organic) | | InChIKey | AWXMSJRRXLCVMW-JVSRKQJHSA-M | | SMILES | [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt Usage And Synthesis |
| Uses | Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2]. | | Biological Activity | Lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist). | | References | [1] Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. PMID:2162349
[2] Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88. DOI:10.1186/1465-9921-10-88
[3] Chaisakul J, et, al. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse". Toxicol Lett. 2012 Sep 3;213(2):243-8. DOI:10.1016/j.toxlet.2012.06.015 |
| | 8-(4-Chlorophenylthio)adenosine-3',5'-cyclic monophosphorothioate, RP-isomer sodium salt Preparation Products And Raw materials |
|