Ghrelin (rat) (acetyl) (trifluoroacetate salt)

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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
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Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
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Ghrelin (rat) (acetyl) (trifluoroacetate salt) Basic information
Product Name:Ghrelin (rat) (acetyl) (trifluoroacetate salt)
Synonyms:Ghrelin (rat) (acetyl) (trifluoroacetate salt)
CAS:
MF:C143H234F3N45O44
MW:3344.6583696
EINECS:
Product Categories:
Mol File:Mol File
Ghrelin (rat) (acetyl) (trifluoroacetate salt) Structure
Ghrelin (rat) (acetyl) (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
Safety Information
MSDS Information
Ghrelin (rat) (acetyl) (trifluoroacetate salt) Usage And Synthesis
DescriptionGhrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).1,2 Ghrelin requires an n-octanoyl modification at serine 3 for binding to the GH secretagogue receptor (GHS-R).3 Ghrelin (rat) (acetyl) is form of ghrelin that is acetylated at serine 3. Acetylated ghrelin is 20-fold less potent than n-octanoyl ghrelin in HEK-293 cells transfected with human GHS-R (IC50 = >2,000 nM; EC50 = 2,000 nM in an aequorin bioluminescence assay).4WARNING This product is not for human or veterinary use.
References[1] MASAYASU KOJIMA. Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J]. Nature, 1999, 402 6762: 656-660. DOI: 10.1038/45230
[2] SUZANNE L. DICKSON . The role of the central ghrelin system in reward from food and chemical drugs[J]. Molecular and Cellular Endocrinology, 2011, 340 1: Pages 80-87. DOI: 10.1016/j.mce.2011.02.017
[3] RESH M D. Fatty acylation of proteins: The long and the short of it[J]. Progress in lipid research, 2016, 63: Pages 120-131. DOI: 10.1016/j.plipres.2016.05.002
[4] MARIA A. BEDNAREK. Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a⊥[J]. Journal of Medicinal Chemistry, 2000, 43 23: 4370-4376. DOI: 10.1021/jm0001727
Ghrelin (rat) (acetyl) (trifluoroacetate salt) Preparation Products And Raw materials
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