BAY-320 manufacturers
- BAY-320
-
- $2800.00
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2026-05-22
- CAS:1445830-50-1
- Purity:
- Supply Ability: 10g
- BAY-320
-
- $2800.00
-
2026-05-21
- CAS:1445830-50-1
- Purity:
- Supply Ability: 10g
- BAY-320
-
- $3310.00
-
2025-07-22
- CAS:1445830-50-1
- Purity:
- Supply Ability: 10g
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| | BAY-320 Basic information |
| Product Name: | BAY-320 | | Synonyms: | BAY-320;BAY320,BAY 320;4-Pyrimidinamine, 2-[5-cyclopropyl-1-[(4-ethoxy-2,6-difluorophenyl)methyl]-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-4-pyridinyl-;2-(5-Cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl)-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine | | CAS: | 1445830-50-1 | | MF: | C26H26F2N6O2 | | MW: | 492.52 | | EINECS: | | | Product Categories: | | | Mol File: | 1445830-50-1.mol |  |
| | BAY-320 Chemical Properties |
| Boiling point | 585.0±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 5.44±0.26(Predicted) | | form | Solid | | color | White to off-white |
| | BAY-320 Usage And Synthesis |
| Uses | BAY-320 is a selective and ATP-competitive Bub1 inhibitor that inhibits the kinase activity of Bub1 with an IC50 of 680 nM. BAY-320 inhibits endogenous Bub1-mediated Sgo1 localization. BAY-320 affects cellular mitotic chromosome arrangement and spindle assembly. BAY-320 inhibits cell proliferation. BAY-320 can be used in the study of cancer[1]. | | References | [1] Amalina I, et al. Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1. R Soc Open Sci. 2021 Dec 15;8(12):210854. DOI:10.1098/rsos.210854
[2] Baron AP, et al. Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524. Elife. 2016 Feb 17;5. pii: e12187. DOI:10.7554/eLife.12187 |
| | BAY-320 Preparation Products And Raw materials |
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