SOD1-Derlin-1 inhibitor 56-59 manufacturers
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| | SOD1-Derlin-1 inhibitor 56-59 Basic information |
| Product Name: | SOD1-Derlin-1 inhibitor 56-59 | | Synonyms: | SOD1-Derlin-1 inhibitor 56-59;Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-N-2-propen-1-yl-6-(3-pyridinyl)-;SOD1-Derlin-1 inhibitor-2;SOD1-Derlin-1 inhibitor 56-59, 10 mM in DMSO;N-Allyl-3-amino-N-phenyl-6-(pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide | | CAS: | 2170170-27-9 | | MF: | C22H18N4OS | | MW: | 386.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2170170-27-9.mol |  |
| | SOD1-Derlin-1 inhibitor 56-59 Chemical Properties |
| Boiling point | 644.3±55.0 °C(Predicted) | | density | 1.321±0.06 g/cm3(Predicted) | | form | Solid | | pka | 3+-.0.12(Predicted) | | color | Light yellow to yellow |
| | SOD1-Derlin-1 inhibitor 56-59 Usage And Synthesis |
| Uses | SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. | | in vivo | SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3mM, flow rate 0.15μL/h) ameliorates ALS pathology in ALS model mice[1]. | Animal Model: | ALS model C57BL/6 mice[1] | | Dosage: | 3mM, flow rate 0.15μL/h | | Administration: | intracerebroventrical injection | | Result: | Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement). |
| | References | [1] Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. DOI:10.1038/s41467-018-05127-2 |
| | SOD1-Derlin-1 inhibitor 56-59 Preparation Products And Raw materials |
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