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| | 7,8-Dihydro-L-biopterin Basic information |
| Product Name: | 7,8-Dihydro-L-biopterin | | Synonyms: | 7,8-dihydrobiopterin;2-AMINO-6-(1R,2S-DIHYDROXYPROPYL)-7,8-DIHYDRO-4(1H)-PTERIDINONE;1-(2-Amino-4-hydroxy-7,8-dihydropteridin-7-yl)propane-1,2-diol;2-Amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-3H-pteridin-4-one;2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro-4(3H)-pteridinone;2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-1H-pteridin-4-one;4(1H)-pteridinone, 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-;L-erythro-7,8-Dihydrobiopterin | | CAS: | 6779-87-9 | | MF: | C9H13N5O3 | | MW: | 239.23 | | EINECS: | 229-641-6 | | Product Categories: | Amines;Bases & Related Reagents;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;All Inhibitors;Inhibitors;Neurochemicals | | Mol File: | 6779-87-9.mol |  |
| | 7,8-Dihydro-L-biopterin Chemical Properties |
| Melting point | >300°C dec. | | Boiling point | 470.8±55.0 °C(Predicted) | | density | 1.88 | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), DMSO (Slightly) | | pka | 10.47±0.20(Predicted) | | form | Solid | | color | Pale Yellow to Brown | | BRN | 536551 | | Stability: | Hygroscopic | | InChI | InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,6-/m0/s1 | | InChIKey | FEMXZDUTFRTWPE-AWFVSMACSA-N | | SMILES | N1C2=C(N=C([C@@H](O)[C@@H](O)C)CN2)C(=O)NC=1N | | CAS DataBase Reference | 6779-87-9 |
| WGK Germany | 3 | | F | 3-10 | | Storage Class | 11 - Combustible Solids |
| | 7,8-Dihydro-L-biopterin Usage And Synthesis |
| Description | BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. | | Chemical Properties | Yellow Powder | | Uses | An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G | | Uses | The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. | | Uses | BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. | | Definition | ChEBI: L-erythro-7,8-dihydrobiopterin is a 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-7,8-dihydrobiopterin. | | references | [1] shen r, alam a, zhang y. inhibition of gtp cyclohydrolase i by pterins[j]. biochimica et biophysica acta (bba)-general subjects, 1988, 965(1): 9-15.
[2] sugiyama t, levy b d, michel t. tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells[j]. journal of biological chemistry, 2009, 284(19): 12691-12700. |
| | 7,8-Dihydro-L-biopterin Preparation Products And Raw materials |
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