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BOC Sciences |
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1-631-485-4226; 16314854226 |
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- IDRA-21
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-
2026-09-15
- CAS:22503-72-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000kg
- Idra 21
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-
2026-09-01
- CAS:22503-72-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000kg
- IDRA21
-
-
2026-08-26
- CAS:22503-72-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 99999
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| | IDRA 21 Basic information |
| Product Name: | IDRA 21 | | Synonyms: | IDRA 21;IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;IDRA 21,98%;7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide;7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide | | CAS: | 22503-72-6 | | MF: | C8H9ClN2O2S | | MW: | 232.69 | | EINECS: | 1592732-453-0 | | Product Categories: | API | | Mol File: | 22503-72-6.mol |  |
| | IDRA 21 Chemical Properties |
| Melting point | 209 °C(Solv: acetic acid (64-19-7)) | | Boiling point | 405.1±55.0 °C(Predicted) | | density | 1.394±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 9.78±0.40(Predicted) | | color | Off-White to Pale Yellow | | InChI | InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3 | | InChIKey | VZRNTCHTJRLTMU-UHFFFAOYSA-N | | SMILES | S1(=O)(=O)C2=CC(Cl)=CC=C2NC(C)N1 |
| Safety Statements | 24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | IDRA 21 Usage And Synthesis |
| Chemical Properties | white to off-white crystalline powder | | Uses | IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960). | | Uses | IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease. | | Definition | ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine. | | Biological Activity | Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ). | | storage | Room temperature |
| | IDRA 21 Preparation Products And Raw materials |
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