|
|
| | (1R,2R)-2-PCCA(hydrochloride) Basic information |
| Product Name: | (1R,2R)-2-PCCA(hydrochloride) | | Synonyms: | (1R,2R)-2-PCCA(hydrochloride);(1R,2R)-2-PCCA 2HCl;2R)-2-PCCA(hydrochloride);(1R,2R)2PCCA hydrochloride,(1R,2R) 2 PCCA hydrochloride;(1R,2R)-N-((2S,3S)-2-Amino-3-methylpentyl)-N-(4'-propyl-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide dihydrochloride;(1R,2R)-2-PCCA hydrochloride, 10 mM in DMSO;(1R,2R)-N-((2S,3S)-2-Amino-3-methylpentyl)-N-(4'-propyl-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide dihydrochloride;(1R,2R)-2-PCCA HCl | | CAS: | 1609563-71-4 | | MF: | C30H38ClN3O | | MW: | 492.1 | | EINECS: | | | Product Categories: | | | Mol File: | 1609563-71-4.mol |  |
| | (1R,2R)-2-PCCA(hydrochloride) Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO : 50 mg/mL (94.60 mM) | | form | Solid | | color | Light yellow to khaki |
| | (1R,2R)-2-PCCA(hydrochloride) Usage And Synthesis |
| Uses | (1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay. | | References | [1] Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1.
[2] Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. DOI:10.1021/cn500082p
[3] Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. DOI:10.1021/acschemneuro.6b00182 |
| | (1R,2R)-2-PCCA(hydrochloride) Preparation Products And Raw materials |
|