151165-96-7
| 中文名称 | 151165-96-7 |
|---|---|
| 中文同义词 | 化合物 T16818;化合物 S-8921 |
| 英文名称 | S-8921 |
| 英文同义词 | S-8921;2-Naphthalenecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-, methyl ester;methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylpentanoyl)-4-hydroxy-6,7,8-trimethoxynaphthalene-2-carboxylate;S 8921,S8921;Methyl-1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate |
| CAS号 | 151165-96-7 |
| 分子式 | C30H36O9 |
| 分子量 | 540.6 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 151165-96-7.mol |
| 结构式 |  |
151165-96-7 性质
| 沸点 | 664.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.176±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 7.00±0.50(Predicted) |
IBAT
S-8921 is an ileal Na + /bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [ 3 H] taurocholate dose-dependently in IBAT-COS cells, and the IC 50 value of S-8921 is 66±8 μM.
Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective.