AZD 5718) manufacturers
- Atuliflapon
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- $44.00
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2026-07-27
- CAS:2041075-86-7
- Purity: 99.28%
- Supply Ability: 10g
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| | AZD 5718) Basic information |
| Product Name: | AZD 5718) | | Synonyms: | Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-;Inhibitor,inhibit,FLAP,AZD-5718,AZD 5718,artery,Atuliflapon,disease,Coronary,5-LO activating protein;(1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide;Atuliflapon (AZD5718);Atuliflapon, 10 mM in DMSO;(1R,2R)-2-(4-(5-Methyl-1H-pyrazol-3-yl)benzoyl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide;Atuliflapon;Unii-NV6352Y6TV | | CAS: | 2041075-86-7 | | MF: | C24H26N6O3 | | MW: | 446.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2041075-86-7.mol |  |
| | AZD 5718) Chemical Properties |
| Boiling point | 851.1±65.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | solubility | DMSO : 125 mg/mL (279.96 mM; Need ultrasonic) | | form | Solid | | pka | 13.12±0.10(Predicted) | | color | White to off-white |
| | AZD 5718) Usage And Synthesis |
| Uses | Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease[1]. | | in vivo | Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively[1].
Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood[1]. | | References | [1] Daniel Pettersen, et al. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem. 2019 May 9;62(9):4312-4324. DOI:10.1021/acs.jmedchem.8b02004 |
| | AZD 5718) Preparation Products And Raw materials |
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