dBET57 manufacturers
- Dbet57
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- $42.00
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2026-09-10
- CAS:1883863-52-2
- Purity: 99.44%
- Supply Ability: 10g
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| Product Name: | dBET57 | | Synonyms: | dBET57;DBET57;DBET 57;DBET-57;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-, (6S)-;inhibit,Dbet-57,dBET 57,Inhibitor,PROTACs,Dbet57,Epigenetic Reader Domain;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide;2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide;Dbet57, 10 mM in DMSO;dBET57 ，S0137 | | CAS: | 1883863-52-2 | | MF: | C34H31ClN8O5S | | MW: | 699.18 | | EINECS: | | | Product Categories: | | | Mol File: | 1883863-52-2.mol |  |
| | dBET57 Chemical Properties |
| density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO: soluble | | form | A solid | | pka | 10.74±0.40(Predicted) | | color | Light yellow to yellow |
| | dBET57 Usage And Synthesis |
| Uses | dBET57 is a BRD4 selective degrader. | | in vivo | dBET57 (7.5 mg/kg, intraperitoneal injection, once daily, 2 weeks) has antitumor activity in the SK-NBE(2) xenograft mouse model[1]. | Animal Model: | SK-NBE(2) xenograft mouse model[1] | | Dosage: | 7.5 mg/kg, daily, 2 weeks | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reduced tumor volume, decreased the proportion of ki-67 positive cells, increased the proportion of caspase3, had no obvious organ toxicity, and downregulated the level of ZMYND8. |
| | IC 50 | BRD4 (BD1): 500 nM (DC50) |
| | dBET57 Preparation Products And Raw materials |
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