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BOC Sciences |
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1-631-485-4226; 16314854226 |
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HSK 0935) manufacturers
- HSK0935
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- $2500.00
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2026-05-11
- CAS:1638851-44-1
- Purity:
- Supply Ability: 10g
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| | HSK 0935) Basic information |
| Product Name: | HSK 0935) | | Synonyms: | HSK 0935);HSK0935 (Synonyms: HSK-0935;HSK0935 (HSK-0935;4R)-Me-Glu;β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-methoxy-;1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-methoxy-β-L-idopyranose | | CAS: | 1638851-44-1 | | MF: | C22H25ClO7 | | MW: | 436.89 | | EINECS: | | | Product Categories: | | | Mol File: | 1638851-44-1.mol |  |
| | HSK 0935) Chemical Properties |
| Boiling point | 597.7±50.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | pka | 12.54±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | HSK 0935) Usage And Synthesis |
| Description | HSK0935 is a potent and highly selective SGLT2 inhibitors (IC50 (hSGLT2) = 1.3 nM; IC50 (hSGLT1) + 1096nM). HSK0935 demonstrated excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold. It showed robust urinary glucose excretion in Sprague-Dawley (SD) rats and affected more urinary glucose excretion in Rhesus monkeys. | | Uses | HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities[1]. | | in vivo | HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys[1].
HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs[1]. | | IC 50 | SGLT2 | | References | [1] Li Y, et al. Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes. J Med Chem. 2017 May 25;60(10):4173-4184. DOI:10.1021/acs.jmedchem.6b01818 |
| | HSK 0935) Preparation Products And Raw materials |
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