(2-pyridyldithio)-PEG4-propargyl

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(2-pyridyldithio)-PEG4-propargyl Basic information
Product Name:(2-pyridyldithio)-PEG4-propargyl
Synonyms:(2-pyridyldithio)-PEG4-propargyl;Pyridine, 2-(3,6,9,12-tetraoxapentadec-14-yn-1-yldithio)-
CAS:2170240-99-8
MF:C16H23NO4S2
MW:357.49
EINECS:
Product Categories:
Mol File:2170240-99-8.mol
(2-pyridyldithio)-PEG4-propargyl Structure
(2-pyridyldithio)-PEG4-propargyl Chemical Properties
Boiling point 465.6±45.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
storage temp. 2-8°C, stored under nitrogen
form Liquid
pka1.81±0.12(Predicted)
color Colorless to light yellow
Safety Information
MSDS Information
(2-pyridyldithio)-PEG4-propargyl Usage And Synthesis
Description(2-pyridyldithio)-PEG4-propargyl is a PEG linker which contains a pyridyl disulfide moiety and a propargyl group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH levels. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
Uses(2-Pyridyldithio)-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
(2-pyridyldithio)-PEG4-propargyl Preparation Products And Raw materials
Tag:(2-pyridyldithio)-PEG4-propargyl(2170240-99-8) Related Product Information
SPDP-PEG4-NHS ester 1,3-Etheno-2H-isoindole-2-pentanoic acid, 1,3-dihydro-δ-oxo (2-pyridyldithio)-PEG2-t-butyl ester (2-pyridyldithio)-PEG4-alcohol Naphthalen-1,4-iMine-9-carboxylic acid, 1,4-dihydro-, 1,1-diMethylethyl ester (2-pyridyldithio)-PEG4 acid