- SPDP-PEG4-NHS ester
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2025-06-07
- CAS:1334177-95-5
- Min. Order: 500mg
- Purity: >99.00%
- Supply Ability: 500mg
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| | SPDP-PEG4-NHS ester Basic information |
| Product Name: | SPDP-PEG4-NHS ester | | Synonyms: | SPDP-PEG4-NHS ester;SDPD-PEG4-NHS;SPDP-dPEG(R)4-NHS ester;NHS-PEG4-SPDP;(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate;Opss-peg(4)-nhs;SPDP-PEG4-NHS;4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 17-oxo-19-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester | | CAS: | 1334177-95-5 | | MF: | C23H33N3O9S2 | | MW: | 559.65 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1334177-95-5.mol |  |
| | SPDP-PEG4-NHS ester Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO, DCM, DMF | | form | solid or viscous liquid | | pka | 15.01±0.46(Predicted) | | color | White or Colorless to Almost white or Almost colorless | | Water Solubility | water: soluble | | InChI | 1S/C23H33N3O9S2/c27-19(7-18-36-37-20-3-1-2-8-25-20)24-9-11-32-13-15-34-17-16-33-14-12-31-10-6-23(30)35-26-21(28)4-5-22(26)29/h1-3,8H,4-7,9-18H2,(H,24,27) | | InChIKey | QTVBGVZVUCIFAH-UHFFFAOYSA-N | | SMILES | O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2 |
| WGK Germany | WGK 3 | | HS Code | 2933.39.9200 | | Storage Class | 11 - Combustible Solids |
| | SPDP-PEG4-NHS ester Usage And Synthesis |
| Description | SPDP-PEG4-NHS ester is a PEG linker containing an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | | Uses | SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | reaction suitability | reagent type: cross-linking reagent | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | SPDP-PEG4-NHS ester Preparation Products And Raw materials |
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