| Company Name: |
LGM Pharma |
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- Nemonapride
-
- $110.00
-
2026-05-11
- CAS:75272-39-8
- Purity:
- Supply Ability: 10g
|
| | NEMONAPRIDE Basic information |
| | NEMONAPRIDE Chemical Properties |
| Melting point | 152-153°C | | Boiling point | 514.941±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.234±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at RT | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 13.686±0.40(predicted) | | form | Solid | | color | White to Off-White | | CAS DataBase Reference | 75272-39-8 |
| | NEMONAPRIDE Usage And Synthesis |
| Description | Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to
have superior efficacy against hallucinations and delusions and also to be effective in
the treatment of negative symptoms. The compound is a benzamide diastereomer and,
although more potent than haloperidol, side effects are reported to be few primarily
akinesia and some muscle rigidity with extrapyramidal symptoms being rare. | | Description | Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM). | | Chemical Properties | Colourless Crystalline Solid | | Originator | Yamanouchi (Japan) | | Uses | Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic. | | Uses | A selective dopamine D2 receptor antagonist. Used as an antipsychotic | | Definition | ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride. | | Brand name | Emirace | | Biological Activity | Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors. | | storage | Store at RT | | References | [1] MICHLO TERAI . SELECTIVE BINDING OF YM-09151-2, A NEW POTENT NEUROLEPTIC, TO D2-DOPAMINERGIC RECEPTORS[J]. Japanese journal of pharmacology, 1983, 33 4: Pages 749-755. DOI: 10.1016/s0021-5198(19)52463-5
[2] RICHARD B MAILMAN Xuemei H. Dopamine receptor pharmacology.[J]. Handbook of clinical neurology, 2007: 77-105. DOI: 10.1016/s0072-9752(07)83004-1
[3] H UJIKE S K K Akiyama. [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma 1 and sigma 2 receptor subtypes.[J]. Neuroreport, 1996, 7 5: 1057-1061. DOI: 10.1097/00001756-199604100-00021
[4] MARIE-BERNADETTE ASSIé Wouter K Cristina Cosi. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine[J]. European journal of pharmacology, 1997, 334 2: Pages 141-147. DOI: 10.1016/s0014-2999(97)01207-7 |
| | NEMONAPRIDE Preparation Products And Raw materials |
|