CGP74514A manufacturers
- CGP74514A
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- $1980.00
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2026-07-14
- CAS:481724-82-7
- Purity: 99.18%
- Supply Ability: 10g
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| | CGP74514A Basic information |
| Product Name: | CGP74514A | | Synonyms: | CGP-74514A hydrochloride
(CGP74514A);N-[(1R,2S)-2-Aminocyclohexyl]-N'-(3-Chlorophenyl)-9-Ethylpurine-2,6-Diamine;N-(CIS-2-AMINOCYCLOHEXYL)-N-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE;AURORA KA-7574;CGP74514A;9H-Purine-2,6-diamine, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-, monohydrochloride, rel- (9CI);2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine:hydrochloride | | CAS: | 481724-82-7 | | MF: | C19H24ClN7.ClH | | MW: | 422.36 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | CGP74514A Chemical Properties |
| | CGP74514A Usage And Synthesis |
| Description | CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and Bcl-x(L). CGP74514A treatment (5 microM; 18 hr) resulted in increased p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2). It also induced early (i.e., within 2 hr) inhibition of CDK1 activity and dephosphorylation of pRb, followed by pRb degradation, but did not block pRb phosphorylation at CDK2- and CDK4- specific sites. These findings indicate that the selective CDK1 inhibitor, CGP74514A , induces complex changes in cell cycle-related proteins in human leukemia cells accompanied by extensive mitochondrial damage, caspase activation, and apoptosis. |
| | CGP74514A Preparation Products And Raw materials |
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