SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 manufacturers
- Sodium cholate hydrate
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- $23.00
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2024-01-08
- CAS:206986-87-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 75000kg/month
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| | SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 Basic information |
| Product Name: | SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 | | Synonyms: | SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9;3,7,12-trihydroxy-, monosodium salt;3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt;Cholalic acid sodium salt;SODIUM CHOLATE HYDRATE, 98 %;SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 96.0% NT DRY MATTER;SODIUM CHOLATE HYDRATE, CELL CULTURE TESTED;SODIUM CHOLATE HYDRATE, PURUM, >= 97.0% NT DRIED MATERIAL | | CAS: | 206986-87-0 | | MF: | C24H43NaO6 | | MW: | 450.59 | | EINECS: | 206-643-5 | | Product Categories: | | | Mol File: | 206986-87-0.mol |  |
| | SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 Chemical Properties |
| RTECS | FZ9600000 | | storage temp. | Store at RT. | | solubility | H2O: 0.1 M, clear | | form | Powder | | color | White | | biological source | bovine bile
ovine bile | | Optical Rotation | [α]20/D +36±2°, c = 0.6% in ethanol (dry matter) | | Water Solubility | Soluble in water. | | BRN | 3582354 | | Hydrophilic-Lipophilic Balance (HLB) | 18 | | InChIKey | WPVYVBXDAUNXSZ-WQYDRJRFNA-N | | SMILES | O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 3-9 | | TSCA | Yes | | HS Code | 29181990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Chronic 3 |
| | SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 Usage And Synthesis |
| Uses | Biochemical solubilizing agent Sodium cholate hydrate is a non-denaturing detergent used for the extraction of membrane proteins. It is involved in the study to assess infiltration of pressurized promoter solutions in a mesoporous silica. Further, it serves as a biochemical solubilizing agent. | | Uses | Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes. | | Uses | Non-denaturing detergent used for extraction of membrane proteins. | | General Description | Sodium cholate hydrate is a non-denaturing, anionic detergent. | | Biochem/physiol Actions | Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease. | | in vivo | Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2]. | Animal Model: | Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)[2] | | Dosage: | 1% (w/w) Cholic acid-supplemented diet | | Administration: | Oral, 14 days | | Result: | Decreases SHP expression and increased CYP2D6 activity. |
| | IC 50 | Human Endogenous Metabolite |
| | SODIUM CHOLATE HYDRATE, BIOCHEMIKA, >= 9 Preparation Products And Raw materials |
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