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| | ADENOSINE AMINE CONGENER (ADAC) Basic information |
| Product Name: | ADENOSINE AMINE CONGENER (ADAC) | | Synonyms: | N6-[4-[[[4-[[[(2-AMinoethyl)aMino]carbonyl]Methyl]-anilino]carbonyl]Methyl]phenyl]adenosine hydrate;ADENOSINE AMINE CONGENER (ADAC);ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate;Adenosine amine congener hydrate;N-[4-[2-[[4-[2-[(2-Aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]adenosine;Adenosine, N-[4-[2-[[4-[2-[(2-aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]-;N-(2-Aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide;P1 receptor,otoprotective,Adenosine amine congener,Adenosine Receptor,loss,hearing,Inhibitor,apoptotic,injury,systemic,A1-adenosine,Cochlear,inhibit,Ca2+,neuroprotective | | CAS: | 96760-69-9 | | MF: | C28H32N8O6 | | MW: | 576.6 | | EINECS: | | | Product Categories: | API | | Mol File: | 96760-69-9.mol |  |
| | ADENOSINE AMINE CONGENER (ADAC) Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | 0.1 M acetic acid: 12 mM | | pka | 13.11±0.70(Predicted) | | form | solid | | color | white |
| Safety Statements | 22-24/25 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 |
| | ADENOSINE AMINE CONGENER (ADAC) Usage And Synthesis |
| Uses | Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2]. | | in vivo | Adenosine amine congener (25-300μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50μg/kg, providing up to 21dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1]. | Animal Model: | Male Wistar rats (8-10 weeks old) treated with noise exposure[1] | | Dosage: | 25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300μg/kg/day | | Administration: | Intraperitoneal injection; daily; for 5 days | | Result: | Most effective in the first 24 hours after noise exposure at doses >50μg/kg, and provided up to 21dB protection (averaged across 8-28kHz).
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| | References | [1] Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489. DOI:10.1155/2014/841489
[2] Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81. DOI:10.1007/s11302-010-9188-5 |
| | ADENOSINE AMINE CONGENER (ADAC) Preparation Products And Raw materials |
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