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| | 5-Fluoroorotic acid hydrate 98 Basic information |
| Product Name: | 5-Fluoroorotic acid hydrate 98 | | Synonyms: | 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylic acid hydrate;5-FOA (5-Fluoroorotic acid), Monohydrate;Fluoroorotic Monohydrate;5-Fluoroorotic Acid Monohydrate (Ultra Pure);5-Fluoroorotic Acid Monohydrate (5-FOA Monohydrate) for molecular biology, 98%;5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid;5-Fluoroorotic acid hydrate 98 | | CAS: | 220141-70-8 | | MF: | C5H3FN2O4.H2O | | MW: | 192.1 | | EINECS: | 678-852-3 | | Product Categories: | | | Mol File: | 220141-70-8.mol |  |
| | 5-Fluoroorotic acid hydrate 98 Chemical Properties |
| Melting point | 278 °C (dec.)(lit.) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Aqueous Base (Heated), DMSO (Sparingly, Heated), Methanol (Sparingly), Water (Sl | | form | Solid | | color | Must be White | | Water Solubility | Soluble in water, dimethyl sulfoxide, 50mg in 1ml (1:1 ammonium hydroxide: water) with gentle heating. | | Merck | 14,4176 | | BRN | 181933 |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | UV7800000 | | HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 5-Fluoroorotic acid hydrate 98 Usage And Synthesis |
| Description | 5-fluoro Orotic acid (5-FOA) is used to detect URA3 gene expression in yeast molecular genetic constructs. Yeast with an active URA3 gene, which encodes orotine-5''-monophosphate decarboxylase, converts 5-FOA to fluorodeoxyuridine, which is toxic to cells. Resistant strains of yeast that carry a mutation in the URA3 gene grow in the presence of 5-FOA if the media is supplemented with uracil. | | Uses | 5-Fluoroorotic Acid, Monohydrate (5-FOA) has become a valuable tool for research in the field of molecular genetics and has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5í-phosphate decarboxylation. | | References | [1] F WINSTON. Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae.[J]. Genetics, 1984, 107 2: 179-197. DOI: 10.1093/genetics/107.2.179 |
| | 5-Fluoroorotic acid hydrate 98 Preparation Products And Raw materials |
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