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Velagliflozin manufacturers
- Velagliflozin
-
- $2520.00
-
2026-05-21
- CAS:946525-65-1
- Purity:
- Supply Ability: 10g
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| | Velagliflozin Basic information |
| Product Name: | Velagliflozin | | Synonyms: | Velagliflozin;Benzonitrile, 2-[(4-cyclopropylphenyl)methyl]-4-β-D-glucopyranosyl- | | CAS: | 946525-65-1 | | MF: | C23H25NO5 | | MW: | 395.46 | | EINECS: | | | Product Categories: | | | Mol File: | 946525-65-1.mol |  |
| | Velagliflozin Chemical Properties |
| Boiling point | 648.6±55.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 13.18±0.70(Predicted) | | form | Solid | | color | White to off-white | | InChIKey | SENUNDCNOYAWGN-GNWYEMQNNA-N | | SMILES | O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(C#N)=C(CC2C=CC(C3CC3)=CC=2)C=1)O |&1:1,2,3,5,9,r| |
| | Velagliflozin Usage And Synthesis |
| Uses | Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity. | | in vivo | Velagliflozin (1 mg/kg; p.o.; single dose) increases cholesterol, albumin, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), and urinary glucose excretion, and decreases respiratory exchange ratio in cats[1].
Velagliflozin (0.3 mg/kg; p.o.; once daily for 18 d) is well tolerated and can improve insulin disorders and prevent laminitis in ponies by reducing the high insulin response of dietary non-structural carbohydrates (NSC)[2].
| | IC 50 | SGLT2 | | References | [1] Hoenig M, et al. Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther. 2018 Apr;41(2):266-273. DOI:10.1111/jvp.12467
[2] Meier A, et al. The sodium-glucose co-transporter 2 inhibitor velagliflozin reduces hyperinsulinemia and prevents laminitis in insulin-dysregulated ponies. PLoS One. 2018 Sep 13;13(9):e0203655. DOI:10.1371/journal.pone.0203655 |
| | Velagliflozin Preparation Products And Raw materials |
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