5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-

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5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Suppliers list
Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- manufacturers

  • BMS-932481
  • BMS-932481 pictures
  • $2780.00
  • 2026-04-21
  • CAS:1263871-36-8
  • Purity:
  • Supply Ability: 10g
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Basic information
Product Name:5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-
Synonyms:5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-;BMS-932481;BMS-932481(BMS932481
CAS:1263871-36-8
MF:C24H24FN7O
MW:445.49
EINECS:
Product Categories:
Mol File:1263871-36-8.mol
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Structure
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Chemical Properties
Safety Information
MSDS Information
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Usage And Synthesis
UsesBMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively[1].
in vivo

BMS-932481 (2-30 mg/kg, po, single dose) reduces the levels of Aβ1-42 and Aβ1-40, increases levels of Aβ1-38 and Aβ1-37, without changing overall amounts of Aβ peptides in dog models[1].
BMS-932481 (2.5-15 mg/kg, iv, single dose) exhibits moderate brain penetration with brain-to-plasma ratio and AUCbrain to AUCplasma ratio of about 0.23 and 0.6 in Sprague-Dawley rats[1].

Animal Model:Beague dog model[1]
Dosage:2-30 mg/kg
Administration:po, single dose
Result:Reduced levels of Aβ1-42 and Aβ1- 40 of 65% with 30 mg/kg dose, increased levels of Aβ1-38 and Aβ1-37 by 1.8 and 5 fold.
References[1] Toyn JH, et al., Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. DOI:10.1124/jpet.116.232249
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- Preparation Products And Raw materials
Tag:5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)-(1263871-36-8) Related Product Information
5H-Cyclopentapyrimidine-2,4-diamine, 7-(4-fluorophenyl)-6,7-dihydro-N2-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-N4-methyl-, (7S)- MRK 560 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid 2H-1,2,4-Oxadiazine, 5-(4-chlorophenyl)-6-cyclopropyl-5,6-dihydro-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)-2-pyridinyl]-, (5R,6S)-rel-(+)- RO7185876 Dibenzazepine