VH 032 phenol-linker 1 manufacturers
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| | VH 032 phenol-linker 1 Basic information |
| Product Name: | VH 032 phenol-linker 1 | | Synonyms: | VH 032 phenol-linker 1;VH 032 phenol-alkylC4-amine;(S,R,S)-AHPC-phenol-C4-NH2 (dihydrochloride);VH 032 phenol-alkylC4-amine dihydrochloride;(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-(4-aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride;(2S,4R)-1-[(S)-2-Acetamido-3,3-dimethylbutanoyl]-N-[2-(4-aminobutoxy)-4-(4-methyl-5-thiazolyl)benzyl]-4-hydroxypyrrolidine-2-carboxamide Dihydrochloride | | CAS: | 2376990-26-8 | | MF: | C28H42ClN5O5S | | MW: | 596.18 | | EINECS: | | | Product Categories: | | | Mol File: | 2376990-26-8.mol |  |
| | VH 032 phenol-linker 1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white |
| | VH 032 phenol-linker 1 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPCbased VHL ligand and a linker used inPROTACtechnology[1]. | | storage | Store at -20°C | | References | [1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery.Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] [3].Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | VH 032 phenol-linker 1 Preparation Products And Raw materials |
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