Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]-

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Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]- Basic information
Product Name:Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]-
Synonyms:Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]-;WAY-616763;2-(3,4-Dichlorophenyl)-N-(4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)acetamide;PFK-IN-1
CAS:735303-62-5
MF:C18H15Cl2N3O4S
MW:440.3
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Mol File:735303-62-5.mol
Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]- Structure
Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]- Chemical Properties
Safety Information
MSDS Information
Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]- Usage And Synthesis
UsesPFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively[1].
References[1] Kyle R Brimacombe, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013 Oct 30;5(1):12-7. DOI:10.1021/ml400259d
Benzeneacetamide, 3,4-dichloro-N-[4-[[(5-methyl-3-isoxazolyl)amino]sulfonyl]phenyl]- Preparation Products And Raw materials
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