- 5-Bromo-1-tetralone
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- $0.00 / 1KG
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2022-01-04
- CAS:68449-30-9
- Min. Order: 1g
- Purity: 98%minHPLC
- Supply Ability: 50kgs/month
- 5-Bromo-1-tetralone
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- $1.00 / 1kg
-
2019-07-06
- CAS:68449-30-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 200kg
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| | 5-Bromo-1-tetralone Basic information |
| Product Name: | 5-Bromo-1-tetralone | | Synonyms: | 5-BROMO-1-TETRALONE;5-BROMOTETRALONE;5-BROMO-3,4-DIHYDRO-1(2H)-NAPHTHALENONE;5-BROMO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;5-Bromo-3,4-dihydro-2H-naphthalen-1-one;5-BROMO-A-TETRALONE;5-broMo-1,2,3,4-tetrahydronaphthalen-1-one;5-Bromo-1-tetralone, 5-Bromo-1-oxo-1,2,3,4-tetrahydronaphthalene | | CAS: | 68449-30-9 | | MF: | C10H9BrO | | MW: | 225.08 | | EINECS: | | | Product Categories: | Benzocycles;CHIRAL CHEMICALS | | Mol File: | 68449-30-9.mol |  |
| | 5-Bromo-1-tetralone Chemical Properties |
| Melting point | 47-48 °C(Solv: methanol (67-56-1)) | | Boiling point | 105-110 °C(Press: 0.3 Torr) | | density | 1.511±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): .15 mg/ml | | form | A crystalline solid | | color | Yellow to brown | | InChI | InChI=1S/C10H9BrO/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1,4-5H,2-3,6H2 | | InChIKey | DMXOUYZZHVHEQR-UHFFFAOYSA-N | | SMILES | C1(=O)C2=C(C(Br)=CC=C2)CCC1 | | CAS DataBase Reference | 68449-30-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | HS Code | 2909309090 |
| | 5-Bromo-1-tetralone Usage And Synthesis |
| Description | 5-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis. | | Uses | 5-Bromotetralone (5-Bromo-3,4-dihydro-2H-naphthalen-1-one) is a synthetic intermediate useful for pharmaceutical synthesis. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 49, p. 4226, 1984 DOI: 10.1021/jo00196a024 | | Synthesis | 7-Bromo-3,4-dihydro-2H-1-naphthalenone and 5-bromo-1-tetrahydronaphthalenone were synthesized using 1-tetralone as starting material with reference to the methodology reported by Cornelius, L.A.M. and Combs, D.W. in Synthetic Communications 1994, 24, 2777-2788. The procedure was as follows: the isomers in the reaction mixture were separated by silica gel fast chromatography (using a Biotage Flash 75 system with an elution solvent ratio of 20:1 hexane/methyl tert-butyl ether) to afford 5-bromo-1-tetralone (11.59 g, 51% yield) and 7-bromo-1-tetralone (9.45 g, 42% yield), respectively. | | References | [1] Patent: WO2005/95326, 2005, A2. Location in patent: Page/Page column 110-111
[2] Patent: WO2004/94384, 2004, A2. Location in patent: Page 63-64
[3] Patent: WO2004/94413, 2004, A1. Location in patent: Page 63-64
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 1, p. 29 - 35
[5] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 16, p. 4405 - 4409 |
| | 5-Bromo-1-tetralone Preparation Products And Raw materials |
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