(DAP22)-SHK manufacturers
- (DAP22)-SHK
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2026-07-27
- CAS:220384-25-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | (DAP22)-SHK Basic information |
| Product Name: | (DAP22)-SHK | | Synonyms: | (DAP22)-SHK;(DAP22)-STICHODACTYLA HELIANTHUS NEUROTOXIN;(DAP22)-STICHODACTYLA HELIANTHUS NEUROTOXIN (SHK);(Dap 22)-Stichodactyla helianthus Neurotoxin (ShK) H-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Dap-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH (Disulfide bonds between Cys3 and Cys35/Cys12 and Cys28/Cys17 and Cys32);ShK-Dap22;H-ARG-SER-CYS-ILE-ASP-THR-ILE-PRO-LYS-SER-ARG-CYS-THR-ALA-PHE-GLN-CYS-LYS-HIS-SER-MET-DAP-TYR-ARG-LEU-SER-PHE-CYS-ARG-LYS-THR-CYS-GLY-THR-CYS-OH;449:PN:WO2010108154 SEQID:317 claimed protein;(Dap??)-Stichodactyla helianthus Neurotoxin (ShK) | | CAS: | 220384-25-8 | | MF: | C166H274N54O48S7 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![(DAP22)-SHK Structure]() |
| | (DAP22)-SHK Chemical Properties |
| storage temp. | -15°C | | form | Powder | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-{Dpr}-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (Disulfide bridge:Cys3-Cys35;Cys12-Cys28;Cys17-Cys32) |
| | (DAP22)-SHK Usage And Synthesis |
| Uses | ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1]. | | storage | Store at -20°C | | References | [1] K Kalman, et al. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide. J Biol Chem. 1998 Dec 4;273(49):32697-707. DOI:10.1074/jbc.273.49.32697 |
| | (DAP22)-SHK Preparation Products And Raw materials |
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