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| | 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Basic information |
| | 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties |
| Melting point | 142.0 to 146.0 °C | | Boiling point | 471.3±45.0 °C(Predicted) | | density | 1.314±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 4.51±0.20(Predicted) | | color | White to Almost white | | CAS DataBase Reference | 5733-86-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | RTECS | UY0686500 | | HazardClass | IRRITANT | | HS Code | 2933790090 |
| | 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (2.00 g, 8.57 mmol) was used as a raw material and dissolved in a mixed solvent of methanol (10 mL) and tetrahydrofuran (10 mL). Subsequently, 2 N aqueous lithium hydroxide (8.6 mL) was added to this solution. The reaction mixture was heated to reflux for 20 minutes. Upon completion of the reaction, the reaction solution was cooled in an ice bath, adjusted to acidity with aqueous potassium bisulfate, and then extracted with ethyl acetate. The organic layers were combined, concentrated and purified by repurification (ethyl acetate/hexane) and dried to give 1-benzyl-5-oxo-3-pyrrolidinecarboxylic acid (1.83 g, 97% yield).1H-NMR (DMSO-d6) δ: 2.56 (2H, m), 3.80 (1H, m), 3.15 (2H, m), 3.25 (2H, m), 4.36 (2H , q, J = 8.6 Hz), 7.27 (5H, m), 12.61 (1H, s). | | References | [1] Patent: EP1403255, 2004, A1. Location in patent: Page 78
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2374 - 2385
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 377 - 379
[4] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[5] Patent: WO2006/123725, 2006, A1. Location in patent: Page/Page column 64-65 |
| | 1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials |
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