Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate

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Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate Basic information
Synthesis
Product Name:Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate
Synonyms:1-BENZYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER;3-Pyrrolidinecarboxylic acid, 5-oxo-1-(phenylmethyl)-, methyl ester;1-Benzyl-5-oxo-3-pyrrolidinecarboxylic acid methyl ester;5-Oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid methyl ester;Methyl 1-benzyl-5-oxo-3-pyrrolidine-carboxylate,98%;Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 97%;Methyl 5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylate;NSC 176916
CAS:51535-00-3
MF:C13H15NO3
MW:233.26
EINECS:257-257-9
Product Categories:Heterocyclic Building Blocks;C13 to C20+;Building Blocks;Chemical Synthesis;Esters;Pyrrolidines;Building Blocks;Heterocyclic Building Blocks
Mol File:51535-00-3.mol
Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate Structure
Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate Chemical Properties
Melting point 63-66 °C (lit.)
Boiling point 375.51°C (rough estimate)
density 1.1475 (rough estimate)
refractive index 1.5310 (estimate)
storage temp. Sealed in dry,Room Temperature
pka-1.82±0.40(Predicted)
form Powder
color White to slightly yellow
InChIInChI=1S/C13H15NO3/c1-17-13(16)11-7-12(15)14(9-11)8-10-5-3-2-4-6-10/h2-6,11H,7-9H2,1H3
InChIKeyWTRWSSDZHQOPJI-UHFFFAOYSA-N
SMILESN1(CC2=CC=CC=C2)C(=O)CC(C(OC)=O)C1
Safety Information
Risk Statements 36/37/38
Safety Statements 24/25-60-37-26
WGK Germany 3
HazardClass IRRITANT
HS Code 29337900
Storage Class13 - Non Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate Usage And Synthesis
SynthesisThe target compound, methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate, was prepared by a one-step cyclization reaction using dimethyl itaconic acid and benzylamine as starting materials. The synthetic reaction formula is shown in the figure below:

Synthesis of 51535-00-3

Chemical Propertieswhite to slightly yellowish powder
UsesEnantiomeric separation of methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate has been achieved using methylchlorophenyl carbamate of cellulose and of amylose as polysaccharide chiral stationary phases by HPLC.
General DescriptionEnantiomeric separation of methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate has been achieved using methylchlorophenyl carbamate of cellulose and of amylose as polysaccharide chiral stationary phases by HPLC.
Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate Preparation Products And Raw materials
Preparation ProductsMethyl 1-Boc-3-pyrrolidinecarboxylate-->1-Benzylpyrrolidin-3-yl-methanol-->3-Pyrrolidinecarboxamide, 5-oxo-1-(phenylmethyl)- -->Methyl 1-Benzyl-5-thioxopyrrolidine-3-carboxylate
Tag:Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate(51535-00-3) Related Product Information
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