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| | Ethyl methyldopate hydrochloride Basic information |
| Product Name: | Ethyl methyldopate hydrochloride | | Synonyms: | methyldopa ethyl hydrochloride;METHYLDOPAETHYLHCL;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methyl-propionic acid ethyl ester hydrochloride;METHYLDOPATE HCL;METHYLDOPATE HYDROCHLORIDE;ethyl methyldopate hydrochloride;Levo-3-(3,4-dihydroxyphenyl)-2-methylalanine ethyl ester hydrochloride;ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate hydrochloride | | CAS: | 2508-79-4 | | MF: | C12H17NO4.ClH | | MW: | 275.73 | | EINECS: | 219-720-3 | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 2508-79-4.mol |  |
| | Ethyl methyldopate hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | form | crystalline powder | | Major Application | pharmaceutical
pharmaceutical small molecule | | InChI | 1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1 | | InChIKey | QSRVZCCJDKYRRF-YDALLXLXSA-N | | SMILES | [Cl-].N[C@](Cc1cc(c(cc1)O)O)(C)C(=O)OCC.[H+] |
| WGK Germany | WGK 3 | | HS Code | 2922504500 | | Storage Class | 11 - Combustible Solids |
| | Ethyl methyldopate hydrochloride Usage And Synthesis |
| Uses | Ethyl methyldopate hydrochloride is Antihypertensive. | | Brand name | Aldomet (Merck). | | General Description | Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter. | | Clinical Use | Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents. | | in vivo | Methyldopate is hydrolysed in vivo to methyldopa[2]. | | IC 50 | α adrenergic receptor |
| | Ethyl methyldopate hydrochloride Preparation Products And Raw materials |
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