- H-Gly-Oet.HCl
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- $0.00 / 1kg
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2026-02-02
- CAS:623-33-6
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Glycine ethyl ester hydrochloride Basic information |
| | Glycine ethyl ester hydrochloride Chemical Properties |
| Melting point | 145-146 °C(lit.) | | density | 1.371 g/cm3 | | storage temp. | 2-8°C | | solubility | >1000 g/L (20 °C) | | pka | pK1:7.66(＋1) (25°C) | | form | Crystalline Powder | | color | White | | Odor | Odorless | | PH | 2.9 (10g/l, H2O, 20℃) | | Water Solubility | >1000 g/L (20 ºC) | | Sensitive | Hygroscopic | | BRN | 3594034 | | Major Application | peptide synthesis | | InChI | 1S/C4H9NO2.ClH/c1-2-7-4(6)3-5;/h2-3,5H2,1H3;1H | | InChIKey | TXTWXQXDMWILOF-UHFFFAOYSA-N | | SMILES | Cl.CCOC(=O)CN | | CAS DataBase Reference | 623-33-6(CAS DataBase Reference) | | EPA Substance Registry System | Glycine, ethyl ester, hydrochloride (623-33-6) |
| Hazard Codes | Xi | | Risk Statements | 41-36/37/38 | | Safety Statements | 26-39-24/25-37/39 | | WGK Germany | 3 | | RTECS | MC0525000 | | TSCA | TSCA listed | | HS Code | 29224995 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1 |
| | Glycine ethyl ester hydrochloride Usage And Synthesis |
| Chemical Properties | Crystalline | | Uses | As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin. | | Uses | Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride. | | Purification Methods | Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.] | | References | [1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
[2] Patent: US2003/236253, 2003, A1. Location in patent: Page 12
[3] Patent: CN107652265, 2018, A. Location in patent: Paragraph 0040; 0041
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 55 - 67
[5] Patent: CN105820102, 2016, A. Location in patent: Paragraph 0038 |
| | Glycine ethyl ester hydrochloride Preparation Products And Raw materials |
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