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| | SUC-ALA-GLU-PRO-PHE-PNA Basic information |
| Product Name: | SUC-ALA-GLU-PRO-PHE-PNA | | Synonyms: | SUC-ALA-GLU-PRO-PHE-PNA;Suc-AEPF-pNA;Suc-Ala-Glu-Pro-Phe-pNA≥ 98% (HPLC);L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-;N-(3-Carboxy-1-oxopropyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide;Peptidyl-Prolyl Isomerase SubstratesSuc-Ala-Glu-Pr;(S)-4-((S)-2-(3-Carboxypropanamido)propanamido)-5-((S)-2-(((S)-1-((4-nitrophenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidin-1-yl)-5-oxopentanoic acid | | CAS: | 128802-76-6 | | MF: | C32H38N6O11 | | MW: | 682.68 | | EINECS: | | | Product Categories: | ADC Linker | | Mol File: | Mol File |  |
| | SUC-ALA-GLU-PRO-PHE-PNA Chemical Properties |
| Boiling point | 1165.357±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.408±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -15°C | | form | Solid | | pka | 4.474±0.10(predicted) | | color | White to off-white | | Sequence | {Suc}-Ala-Glu-Pro-Phe-{pNA} |
| | SUC-ALA-GLU-PRO-PHE-PNA Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc[1][2]. | | References | [1] Subedi A, et al. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-533. DOI:10.1016/j.bbrc.2016.04.124
[2] Liu C, et al. Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep. 2017 May;15(5):3210-3214. DOI:10.3892/mmr.2017.6399 |
| | SUC-ALA-GLU-PRO-PHE-PNA Preparation Products And Raw materials |
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