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L-Glutamic acid gamma-(p-nitroanilide) hydrochloride manufacturers
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| | L-Glutamic acid gamma-(p-nitroanilide) hydrochloride Basic information |
| Product Name: | L-Glutamic acid gamma-(p-nitroanilide) hydrochloride | | Synonyms: | H-GLU(PNA)-OH HCL;L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE;L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;l-glutamic acid γ-(p-nitroanilide) hydrochloride;L-Glutamic acid g-(p-nitroanilide) hydrochloride;L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure;(4-amino-1-carboxy-4-keto-butyl)-(4-nitrophenyl)ammonium chloride | | CAS: | 67953-08-6 | | MF: | C11H14ClN3O5 | | MW: | 303.7 | | EINECS: | 267-944-5 | | Product Categories: | | | Mol File: | 67953-08-6.mol |  |
| | L-Glutamic acid gamma-(p-nitroanilide) hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble in Water (up to 5 mg/ml). | | form | solid | | color | Off-white | | Water Solubility | water: 5mg/mL, clear, yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. | | InChI | 1S/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H | | InChIKey | OJEVFSFTVARWQX-UHFFFAOYSA-N | | SMILES | Cl.NC(CCC(=O)Nc1ccc(cc1)N(=O)=O)C(O)=O | | EPA Substance Registry System | L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | TSCA | TSCA listed | | Storage Class | 11 - Combustible Solids |
| | L-Glutamic acid gamma-(p-nitroanilide) hydrochloride Usage And Synthesis |
| Description | L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3 | | Uses | L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway. | | IC 50 | ASCT2 | | References | [1] COOPER A J, GRIFFITH O. γ‐Glutamyl Transpeptidase[C]. 2002: 0. DOI:10.1002/0471203076.emm0514
[2] C. SEAN ESSLINGER Joseph F R Kimberly A Cybulski. Nγ-Aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site[J]. Bioorganic & Medicinal Chemistry, 2005, 13 4: Pages 1111-1118. DOI:10.1016/j.bmc.2004.11.028
[3] PAUL NICKLIN. Bidirectional transport of amino acids regulates mTOR and autophagy.[J]. Cell, 2009: 521-534. DOI:10.1016/j.cell.2008.11.044 |
| | L-Glutamic acid gamma-(p-nitroanilide) hydrochloride Preparation Products And Raw materials |
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