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| | 4-Chloro-2-methoxybenzaldehyde Basic information |
| Product Name: | 4-Chloro-2-methoxybenzaldehyde | | Synonyms: | 2-Methoxy-4-chlorbenzaldehyd;Benzaldehyde, 4-chloro-2-methoxy-;4-Fluoro-4-(trifluoromethyl)phenacyl bromide;2-Methoxy-4-chlorobenzaldehyde;4-Chloro1-formyl-2-methoxybenzene;4-Chloro-2-methoxybenzaldehyde | | CAS: | 53581-86-5 | | MF: | C8H7ClO2 | | MW: | 170.59 | | EINECS: | | | Product Categories: | | | Mol File: | 53581-86-5.mol |  |
| | 4-Chloro-2-methoxybenzaldehyde Chemical Properties |
| Melting point | 70-75°C | | Boiling point | 268.8±20.0 °C(Predicted) | | density | 1.244±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | Appearance | Off-white to light yellow Solid | | InChI | 1S/C8H7ClO2/c1-11-8-4-7(9)3-2-6(8)5-10/h2-5H,1H3 | | InChIKey | IVBZHFWJBYTRNG-UHFFFAOYSA-N | | SMILES | COc1cc(Cl)ccc1C=O |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | WGK Germany | 3 | | HS Code | 2913000090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal |
| | 4-Chloro-2-methoxybenzaldehyde Usage And Synthesis |
| Synthesis | The reaction was carried out with 2-fluoro-4-chlorobenzaldehyde (300 mg, 1.89 mmol) and sodium methanol (3784 μL, 1.89 mmol, methanol solution) with stirring at 50 °C for 3 hours. Upon completion of the reaction, the reaction mixture was concentrated to half of the original volume and subsequently purified by Biotage 25 column chromatography using 5% ethyl acetate/hexane as eluent to finally obtain 4-chloro-2-methoxybenzaldehyde (250 mg, 1.47 mmol, 77.5% yield). | | References | [1] Patent: WO2009/158426, 2009, A1. Location in patent: Page/Page column 140
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 18, p. 5037 - 5041
[3] Angew. Chem., 2018, vol. 130, # 18, p. 5131 - 5135,5 |
| | 4-Chloro-2-methoxybenzaldehyde Preparation Products And Raw materials |
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