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| | Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-, ethyl ester Basic information |
| | Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-, ethyl ester Chemical Properties |
| Boiling point | 286.4±20.0 °C(Predicted) | | density | 1.102±0.06 g/cm3(Predicted) | | pka | 14.35±0.10(Predicted) |
| | Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-, ethyl ester Usage And Synthesis |
| Uses | PEG2-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | PEG2-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Acetic acid, 2-[2-(2-hydroxyethoxy)ethoxy]-, ethyl ester Preparation Products And Raw materials |
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