Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate manufacturers
- Ossirene
-
- $56.00
-
2026-09-10
- CAS:106566-58-9
- Purity: 98.00%
- Supply Ability: 10g
|
| | Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate Basic information |
| Product Name: | Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate | | Synonyms: | AS 101;CTK8E8213;CTK8E8213;RT-011323;RT-011323;Interleukin Related;RPE,NFκB,AS 101,Caspase,Inhibitor,inhibit,AS-101,diseases,immunomodulatory,Ossirene,autoimmune,malignancies,tellurium,IL-6,IL-8,p65,Interleukin Related,STAT3,phosphorylation;Ossirene (AS101);Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate | | CAS: | 106566-58-9 | | MF: | C2H4Cl3O2Te.H4N | | MW: | 312.049 | | EINECS: | | | Product Categories: | | | Mol File: | 106566-58-9.mol | ![Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate Structure](CAS/GIF/106566-58-9.gif) |
| | Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO | | form | solid | | color | White crystalline |
| | Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate Usage And Synthesis |
| Uses | AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy. | | Biological Activity | Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release. | | in vivo | Ossirene (AS101; 0.5 mg/kg/day; IP; 25 days) sensitizes GBM tumors to paclitaxel via inhibition of IL-10, resulting in increased survival[2].
| Animal Model: | SCID mice with GBM cells[2] | | Dosage: | 0.5 mg/kg | | Administration: | IP; daily; 25 days | | Result: | Significantly increased survival of GBM tumor-bearing mice.
|
| | IC 50 | IL-1β; IL-6; IL-8; IL-10; Caspase-1 | | references | [1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.
[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.
[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.
[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.
[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392. |
| | Ammonium trichloro[1,2-ethanediolato-o,o']-tellurate Preparation Products And Raw materials |
|