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| | 3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine Basic information |
| Product Name: | 3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine | | Synonyms: | 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-chloro-3-(phenylmethyl)-;3-benzyl-7-chlorotriazolo[4,5-d]pyrimidine;3-benzyl-7-chloro-3h - [1,2,3] thiazol [4,5-d] pyrimidine;3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine | | CAS: | 21410-06-0 | | MF: | C11H8ClN5 | | MW: | 245.67 | | EINECS: | | | Product Categories: | Heterocycle-Pyrimidine series | | Mol File: | 21410-06-0.mol | ![3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine Structure](CAS/GIF/21410-06-0.gif) |
| | 3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine Chemical Properties |
| Boiling point | 454.9±35.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 0.98±0.30(Predicted) |
| | 3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-benzyl-7-chloro-3H-[1,2,3]-triazolo[4,5-d]pyrimidines from 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol: To chloroform (50 mL) containing 3-benzyl-7-hydroxy-3H-[1,2,3]triazolo[4,5-d]pyrimidines (10.56 mmol) suspension, N,N-dimethylformamide (DMF, 2 mL) and thionyl chloride (9 mL) were added sequentially. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure at a temperature below 35 °C. The crude product was purified by silica gel column chromatography with mixed petroleum ether-ethyl acetate solvent as eluent. The final white solid product 3-benzyl-7-chloro-3H-[1,2,3]-triazolo[4,5-d]pyrimidine (1.14 g, 44% yield) was obtained. | | References | [1] Patent: EP1598354, 2005, A1. Location in patent: Page/Page column 88 |
| | 3-Benzyl-7-chloro-3H-[1,2,3]triazolo[4,5-d]pyrimidine Preparation Products And Raw materials |
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