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| | Niclosamide ethanolamine salt Basic information |
| Product Name: | Niclosamide ethanolamine salt | | Synonyms: | Ethanolamine salt Niclosamide;Bayluscid[R];Clonitralide;2'',5-DICHLORO-4''-NITROSALICYLANILIDE(NICLOSAMIDE);BAYER73;2',5-Dichloro-4'-nitrosalicylanilide 2-aminoethanol salt;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 2-aminoethanol salt;Snanilcide | | CAS: | 1420-04-8 | | MF: | C15H15Cl2N3O5 | | MW: | 388.2 | | EINECS: | 215-811-7 | | Product Categories: | | | Mol File: | 1420-04-8.mol |  |
| | Niclosamide ethanolamine salt Chemical Properties |
| Melting point | 204° | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL; Ethanol: 0.25 mg/mL | | form | A crystalline solid | | color | Light yellow to yellow | | Henry's Law Constant | 2.6×104 mol/(m3Pa) at 25℃, HSDB (2015) | | Stability: | Stable. Hydrolyzes in concentrated acidic or basic solutions. | | CAS DataBase Reference | 1420-04-8(CAS DataBase Reference) | | EPA Substance Registry System | Clonitralid (1420-04-8) |
| RIDADR | UN2588 (Pesticide, solid, poi-
sonous, n.o.s.); UN2902 (Pesticide, liquid, poisonous,
n.o.s.) | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1 | | Hazardous Substances Data | 1420-04-8(Hazardous Substances Data) | | Toxicity | LD50 oral in rat: 500mg/kg |
| | Niclosamide ethanolamine salt Usage And Synthesis |
| Chemical Properties | Depending on purity, a bright yellow or brownish-yellow crystalline solid or powder. Odorless. Soluble in water | | Uses | The ethanolamine salt as a molluscicide. | | Production Methods | The production of niclosamide-olamine begins with the synthesis of niclosamide, typically via a condensation reaction between 5-chlorosalicylic acid and 2-chloro-4-nitroaniline in the presence of a chlorinating agent such as phosphorus trichloride, often carried out in a solvent like chlorobenzene at elevated temperatures. The resulting niclosamide is then purified through recrystallisation. To form the ethanolamine salt (niclosamide-olamine), niclosamide is reacted with monoethanolamine under controlled pH and temperature conditions, producing a more water-soluble and bioavailable compound suitable for veterinary formulations. | | General Description | Yellow solid. Insoluble in water. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | Niclosamide ethanolamine salt is hydrolyzed by concentrated acid or alkali. | | Fire Hazard | Flash point data for Niclosamide ethanolamine salt are not available. Niclosamide ethanolamine salt is probably combustible. | | Agricultural Uses | Molluscicide: Niclosamide, the parent chemical, is a relatively
selective, non-cumulative chlorinated aromatic amide pesticide. Clonitralid (ethanolamine salt of Niclosamide) is
used principally against molluscs, especially fresh water
snails and to control sea lamprey larvae and also as an antiparasitic drug in human, pets and livestock. Niclosamide is
toxic to all fish species at 0.5 mg/L (48 hours). A U.S. EPA
restricted Use Pesticide as Niclosamide. Limited to use by
a certified applicator [40 CFR 152.175 (a) (7/1/94)]. Not
listed for use in EU countries. Registered for use in
the U.S. | | Trade name | BAY 73® and U.S. Fish and Wildlife
Service; BAY 6076®; BAYER 73®; BAYER 25648®;
BAYLUSCID®[C]; BAYLUSCIDE® and U.S. Fish and
Wildlife Service; M 73®; MOLLUSCICIDE BAYER
73®; NICLOSAMIDE®; SR 73® | | Biological Activity | Cell permeable: yes | | Mechanism of action | Respiratory & stomach action. Acts by uncoupling oxidative phosphorylation in the tapeworm | | Potential Exposure | Niclosamide, the parent chemical, is a relatively selective, noncumulative chlorinated aromatic amide pesticide. Clonitralid (ethanolamine salt of niclosamide) is used principally against molluscs, especially fresh water snails and to control sea lamprey larvae and also as an antiparasitic drug in human, pets, and livestock. Niclosamide is toxic to all fish species at 0.5 mg/L (48 hours). A restricted use pesticide in the United States. Limited to use by a certified applicator . Not listed for use in EU countries. | | Shipping | UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticides, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | | Incompatibilities | Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Hydrolyzed by strong acids, and alkalies. Slowly hydrolyzes in water, releasing ammonia and forming acetate salts. Decomposes at B200-205°C. | | Waste Disposal | Do not discharge into drains or sewers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Burn in incinerator specifically designed for pesticide disposal or dispose as a hazardous waste in a landfill approved and licensed for the disposal of pesticides. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations | | Pesticide Type | Fungicide; Molluscicide; Nematicide; Veterinary substance; Teniacide |
| | Niclosamide ethanolamine salt Preparation Products And Raw materials |
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