4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile

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Company Name: Shandong Territorial sea Biological Technology Co., LTD  
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Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile Basic information
Product Name:4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile
Synonyms:CYP19A1/CYP11B2-IN-1;4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile
CAS:183500-36-9
MF:C12H11N3O
MW:213.23524
EINECS:
Product Categories:
Mol File:183500-36-9.mol
4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile Structure
4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile Usage And Synthesis
UsesCYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC50s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer[1].
References[1] Tinivella A, et al. Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. ACS Pharmacology & Translational Science. 2023 Nov 23. DOI:10.1021/acsptsci.3c00183
4-(5-Hydroxymethylimidazol-1-ylmethyl)benzonitrile Preparation Products And Raw materials
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