6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride

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Products Intro: Product Name:Etifoxine hydrochloride；HOE 36-801 hydrochloride
CAS:56776-32-0
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CAS:56776-32-0
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CAS:56776-32-0
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Products Intro: Product Name:Etifoxine Hydrochloride
CAS:56776-32-0
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Products Intro: Product Name:Etifoxine HCl
CAS:56776-32-0
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6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride manufacturers

  • Etifoxine Hydrochloride
  • Etifoxine Hydrochloride pictures
  • $15.00 / 1KG
  • 2021-07-02
  • CAS:56776-32-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Basic information
Product Name:6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
Synonyms:6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride;Etifoxine·hydrochloride;6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride;2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride;6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride;StresaM;6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride;HOE-36801 hydrochloride
CAS:56776-32-0
MF:C17H18Cl2N2O
MW:337.24362
EINECS:260-380-0
Product Categories:Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API
Mol File:56776-32-0.mol
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Structure
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Chemical Properties
Melting point ND
storage temp. -20°C
solubility DMSO: ≥5mg/mL
form powder
color white to beige
Stability:Hygroscopic
InChI1S/C17H17ClN2O.ClH/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3,(H,19,20);1H
InChIKeySCBJXEBIMVRTJE-UHFFFAOYSA-N
SMILESCl.CCNC1=Nc2ccc(Cl)cc2C(C)(O1)c3ccccc3
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Usage And Synthesis
Chemical PropertiesLow Melting White Solid
UsesEtifoxine hydrochloride has been used as a γ-aminobutyric acid (GABA)-receptor agonist to study its effects on insulin expression in α cell line (αTC1)
UsesPsychotropic agent with anxiolytic and anticonvulsant activity.
Biochem/physiol ActionsEtifoxine is an anxiolytic anticonvulsant, which promotes axonal regeneration. It binds to β2 and β3 subunits of the GABAA receptor complex, a different target site to benzodiazepines, and binds to the translocator protein (18 kDa) TSPO, formerly known as the peripheral or mitochondrial benzodiazepine receptor. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. Whereas, its anxiolytic effects involve GABAA receptors and TSPO, etifoxine′s neuroregenerative effects mainly involve TSPO.
in vivo

Etifoxine competitively inhibits [35S]TBPS binding with micromolar potency in rat brain[1].
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice[3].

Animal Model:Six-week old BALB/cByJ and C57BL/6J mice (20-25 g)[3].
Dosage:3.125-50 mg/kg.
Administration:Intraperitoneal inhection.
Result:Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.
BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.
storageStore at +4°C
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride Preparation Products And Raw materials
Tag:6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride(56776-32-0) Related Product Information
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