4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZINE-1-ETHANOL DIHYDROCHLORIDE
| 中文名称 | 4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZINE-1-ETHANOL DIHYDROCHLORIDE |
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| 中文同义词 | 奋乃静-[D8]盐酸盐;化合物 PERPHENAZINE DIHYDROCHLORIDE;奋乃静-D8*2HCL;奋乃静盐酸盐;奋乃静-[D8]盐酸盐/精确称量 |
| 英文名称 | 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride |
| 英文同义词 | 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride;PERPHENAZINE HCL;Perphenazine hydrochloride;Perphenazine D8 DihydrochlorideQ: What is Perphenazine D8 Dihydrochloride Q: What is the CAS Number of Perphenazine D8 Dihydrochloride Q: What is the storage condition of Perphenazine D8 Dihydrochloride Q: What are the applications of Perphenazine D8 Dihydrochloride;Perphenazine DiHCl (Fluphenazine Dihydrochloride EP Impurity E DiHCl) |
| CAS号 | 2015-28-3 |
| 分子式 | C21H28Cl3N3OS |
| 分子量 | 476.89052 |
| EINECS号 | 2179446 |
| 相关类别 | 有机中间体;临床检测标准物质 |
| Mol文件 | 2015-28-3.mol |
| 结构式 | ![4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZINE-1-ETHANOL DIHYDROCHLORIDE 结构式](CAS/GIF/2015-28-3.gif) |
4-[3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL]PIPERAZINE-1-ETHANOL DIHYDROCHLORIDE 性质
| 颜色 | 晶体 |
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Perphenazine dihydrochloride 是一种具有口服活性的多巴胺受体 (dopamine receptor) 和组胺-1 受体 (histamine-1 receptor) 拮抗剂, Ki 值分别为 0.56 nM (D2)、0.43 nM (D3)、0.6 nM (5-HT2A)。Perphenazine dihydrochloride 还可与 Alpha-1A 肾上腺素受体 (Alpha-1A adrenergic receptor) 结合。Perphenazine dihydrochloride 抑制癌细胞增殖，并诱导细胞凋亡 (apoptosis)。Perphenazine dihydrochloride 可用于精神疾病、癌症、炎症的研究。
安全信息
| 毒性 | LD50 orl-rat: 318 mg/kg 27ZQAG -,36,72 |
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