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| | (2-Azidoacetyl)glycylglycine Basic information |
| | (2-Azidoacetyl)glycylglycine Chemical Properties |
| form | crystalline powder | | pka | 3.309±0.10(predicted) | | color | White |
| | (2-Azidoacetyl)glycylglycine Usage And Synthesis |
| Uses | N3-Gly-Gly-Gly-OH is a oligo-Gly click chemistry reagent containing an azide group. Oligo-Gly also has been used as linker to combine different subunits of dimeric or oligomeric proteins or to create artificial multi-domain proteins. By modification into Gly-Gly-Gly-Ser motifs high solubility can be achieved[1][2][3]. N3-Gly-Gly-Gly-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Imanishi M, et al. DNA-bending finger: artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending. Biochemistry. 2000 Apr 18;39(15):4383-90. DOI:10.1021/bi992989b
[2] Tsygankova SV, et al. Biantennary oligoglycines and glyco-oligoglycines self-associating in aqueous medium. Beilstein J Org Chem. 2014 Jun 17;10:1372-82. DOI:10.3762/bjoc.10.140
[3] Hashii N, et al. [Site-specific O-Glycosylation Analysis of Therapeutic Fc-fusion Protein by Mass Spectrometry]. Yakugaku Zasshi. 2018;138(12):1483-1494. Japanese. DOI:10.1248/yakushi.18-00020-2 |
| | (2-Azidoacetyl)glycylglycine Preparation Products And Raw materials |
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