| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
|
| | KRIBB 3 Basic information |
| Product Name: | KRIBB 3 | | Synonyms: | KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole);4-ethyl-3-methoxy-6-[4-(4-methoxyphenyl)-2H-isoxazol-5-ylidene]-1-cyclohexa-2,4-dienone;Phenol, 4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]-;4-Ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-5-isoxazolyl]phenol;KRIBB3 (5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole), Hsp27 inhibitor | | CAS: | 129414-88-6 | | MF: | C19H19NO4 | | MW: | 325.36 | | EINECS: | | | Product Categories: | | | Mol File: | 129414-88-6.mol |  |
| | KRIBB 3 Chemical Properties |
| Melting point | 147-148 °C | | Boiling point | 467.5±45.0 °C(Predicted) | | density | 1.181±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: 25 mM | | form | A solid | | pka | 8.51±0.48(Predicted) |
| Hazard Codes | Xn | | Risk Statements | 22 | | RIDADR | UN 2811 6.1/PG 3 |
| | KRIBB 3 Usage And Synthesis |
| Uses | Kribb3 is an inhibitor for microtubule. KRIBB3 inhibits the proliferation of cancer cells with GI50 of 0.2-2.5 μM, arrests cell cycle at G2/M phase, and induces apoptosis in HCT-116. Kribb3 exhibits antitumor activity in mouse models[1]. | | References | [1] Shin KD, et al., KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochem Pharmacol. 2008 Jan 15;75(2):383-94. DOI:10.1016/j.bcp.2007.08.027 |
| | KRIBB 3 Preparation Products And Raw materials |
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