1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-

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1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- manufacturers
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Basic information
Product Name:1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-
Synonyms:1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-;5-Aza-4-thio-2-deoxycytidine;Aza-T-dCyd;4-Amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one;4'-thio-5-aza-2-deoxycytidine;5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd);NTX-301;5-Aza-T-dCyd
CAS:169514-76-5
MF:C8H12N4O3S
MW:244.27
EINECS:
Product Categories:
Mol File:169514-76-5.mol
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Structure
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Chemical Properties
Boiling point 495.4±55.0 °C(Predicted)
density 1.91±0.1 g/cm3(Predicted)
pka13.95±0.60(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Usage And Synthesis
Uses2'-Deoxy-4'-thio-5-azacytidine-15N4 is an isotopic labelled compound of 2'-Deoxy-4'-thio-5-azacytidine (D211885). 2'-Deoxy-4'-thio-5-azacytidine is used in the preparation of 5-azacytosine nucleosides with potential anticancer properties.
in vivo

5-Aza-4'-thio-2'-deoxycytidine (6.7, 10 mg/kg/day; IP; for 9 days) is effective against NCI-H23 tumor xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (5 mg/kg/day; IP; for 9 days) decreases DNMT1 levels in tumors of CCRF-CEM tumors mice xenografts[1].
5-Aza-4'-thio-2'-deoxycytidine (1.5 mg/kg; ip; QD×5 rest and repeat 3 cycles) provides modest suppression of tumor growth as well in the HCT116 colon carcinoma, OVCAR3 ovarian tumor xenograft model. 5-Aza-4'-thio-2'-deoxycytidine has minimal antitumor effect in the HL-60 leukemia xenografts[2].

Animal Model:Young female athymic nu/nu mice with NCI-H23 tumor fragment[1]
Dosage:6.7 or 10 mg/kg
Administration:IP; daily for 9 days
Result:Had antitumor efficacy against NCI-H23 tumor xenografts.
IC 50DNMT1
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)- Preparation Products And Raw materials
Tag:1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-deoxy-4-thio-β-D-erythro-pentofuranosyl)-(169514-76-5) Related Product Information
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