Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1)

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Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
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Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) manufacturers
Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) Basic information
Product Name:Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1)
Synonyms:Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1);WF-536 Hydrochloride;WF 536 Hydrochloride,WF536 Hydrochloride;WF-536
CAS:539857-64-2
MF:C14H16ClN3O
MW:277.75
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Mol File:539857-64-2.mol
Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) Structure
Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) Chemical Properties
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Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) Usage And Synthesis
DescriptionWF-536 Hydrochloride is a novel inhibitor of ROCK, inhibiting tumour metastasis in some animal models.
UsesWF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1].
in vivo

WF-536 (oral; 0.3-3 mg/kg/day; for 28 days) inhibits Lewis lung carcinoma (LLC) metastasis and LLC-induced angiogenesis in mice[1].

Animal Model:C57BL/6 mice (male, 6-week old)[1]
Dosage:0.3, 1, 3 mg/kg
Administration:Oral; daily; for 28 days
Result:Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg).
References[1] Nakajima, Masahide et al. Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions. European journal of pharmacology vol. 459,2-3 (2003): 113-20. DOI:10.1016/s0014-2999(02)02869-8
Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1) Preparation Products And Raw materials
Tag:Benzamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, hydrochloride (1:1)(539857-64-2) Related Product Information
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