3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

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3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester manufacturers
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Basic information
Product Name:3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
Synonyms:3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester;αGlucosidaseIN23;α-Glucosidase-IN-23;α-Glucosidase-IN-23, 10 mM in DMSO;2-{[4-(4-chlorophenyl)-1-(4-methylphenyl)-1H-imidazol-2-yl]sulfanyl}-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone;3,5-diethyl 4-(1,3-dioxaindan-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;3,5-diethyl 4-(2H-1,3-benzodioxol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;a-Glucosidase-IN-23
CAS:161187-57-1
MF:C20H23NO6
MW:373.4
EINECS:
Product Categories:
Mol File:161187-57-1.mol
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Structure
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Chemical Properties
Boiling point 481.5±45.0 °C(Predicted)
density 1.225±0.06 g/cm3(Predicted)
pka3.06±0.70(Predicted)
Safety Information
MSDS Information
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Usage And Synthesis
Usesα-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].
in vivo

α-Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits a-glucosidase in mice[1].

Animal Model:Mice[1]
Dosage:0.2 mmol/kg
Administration:Oral; 0.2 mmol/kg/day
Result:
Cmax (nmol/mL)Tmax (h)T1/2(h)AUC (ng/h/mL)
10.11 ± 1.170.8 ± 0.01.90 ± 1.0436.7 ± 2.23
References[1] Peter A Sidhom, et al. Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species. J Med Chem. 2023 Jan 12;66(1):991-1010. DOI:10.1021/acs.jmedchem.2c01818
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Preparation Products And Raw materials
Tag:3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester(161187-57-1) Related Product Information
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