alpha-Guanidinoglutaric acid

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alpha-Guanidinoglutaric acid Basic information
Product Name:alpha-Guanidinoglutaric acid
Synonyms:GGA;Guanidinoglutaricacid;A-GUANIDINOGLUTARIC ACID;(S)-(-)-2-GUANIDINOGLUTARIC ACID 98+%;alpha-Guanidinoglutaric;2-Guanidinopentanedioic acid;(S)-(-)-2-Guanidinoglutaric Acid;(S)-(-)-2-GUANIDINOGLUTARIC ACID
CAS:73477-53-9
MF:C6H11N3O4
MW:189.17
EINECS:
Product Categories:amino acids
Mol File:73477-53-9.mol
alpha-Guanidinoglutaric acid Structure
alpha-Guanidinoglutaric acid Chemical Properties
Boiling point 414.7±55.0 °C(Predicted)
density 1.62±0.1 g/cm3(Predicted)
refractive index -20 ° (C=4, 2mol/L HCl)
storage temp. 2-8°C
solubility PBS pH 7.2: >50 mg/ml
pka3.28±0.10(Predicted)
form White crystalline solid.
color White to Almost white
Safety Information
HS Code 2925.29.6000
MSDS Information
alpha-Guanidinoglutaric acid Usage And Synthesis
DescriptionGGA is a linear mixed-type inhibitor of nNOS having a Ki of 2.69 μM. It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.
Usesα-Guanidinoglutaric acid is a guanidino compound first found in cobaltinduced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric acid induces epileptic seizures in rats after intraventricular administration[1].
DefinitionChEBI: N-Amidino-L-glutamate is a L-glutamic acid derivative.
References[1] H Shiraga, et al. Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. J Neurochem. 1986 Dec;47(6):1832-6. DOI:10.1111/j.1471-4159.1986.tb13095.x
alpha-Guanidinoglutaric acid Preparation Products And Raw materials
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Mifepristone alpha-Guanidinoglutaric acid (S)-(-)-2-Guanidinoglutaric acid S-methylisothiourea salt α-guaiene,guaia-1(5),11-diene,[1S-(1a,4a,7a)]-1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethenyl)-azulene 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester 2H-Benzimidazole-2-thione, 5-[[(2,4-dihydroxyphenyl)methylene]amino]-1,3-dihydro- 2-Propenoic acid, 3-(4-methylphenyl)-, 2-oxo-2H-1-benzopyran-4-yl ester, (2E)- α-Glucosidase-IN-29 KRN7000 α-galactosidase 5H-Indeno[1,2-b]pyridin-5-one, 6,7-dimethoxy-4-methyl- Benzoic acid, 4-[2-[(Z)-(4,5-dihydro-6-methyl-3,4-dioxofuro[3,4-c]pyridin-1(3H)-ylidene)methyl]-5-(hydroxymethyl)-1H-pyrrol-1-yl]-, ethyl ester 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-(phenylthio)- Benzenesulfonamide, N-[4-[5-(4-chlorophenyl)-1-oxo-2,4-pentadien-1-yl]phenyl]-4-(trifluoromethyl)- 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-bromo-3,5-dimethoxyphenyl)-6-(phenylthio)-