15(S)-HETRE

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15(S)-HETRE manufacturers

  • 15(S)-HETrE
  • 15(S)-HETrE pictures
  • $993.00
  • 2026-07-15
  • CAS:92693-02-2
  • Purity:
  • Supply Ability: 10g
15(S)-HETRE Basic information
Product Name:15(S)-HETRE
Synonyms:IUKXMNDGTWTNTP-OAHXIXLCSA-N;15(S)-HETRE;15S-HYDROXY-8Z,11Z,13E-EICOSATRIENOIC ACID;15(S)-HYDROXYEICOSA-8Z, 11Z, 13E-TRIENOIC ACID;15(S) HETrE,15(S)HETrE;8,11,13-Eicosatrienoic acid, 15-hydroxy-, (8Z,11Z,13E,15S)-
CAS:92693-02-2
MF:C20H34O3
MW:322.48
EINECS:
Product Categories:
Mol File:92693-02-2.mol
15(S)-HETRE Structure
15(S)-HETRE Chemical Properties
Boiling point 487.4±40.0 °C(Predicted)
density 0.971±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
pka4.77±0.10(Predicted)
Safety Information
MSDS Information
15(S)-HETRE Usage And Synthesis
Description15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid (DGLA; ). It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM.1 In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.2
Uses15(S)-HETRE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.
References1. Petrich, K., Ludwig, P., Kühn, H., et al. The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leukocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: Structure-activity relationship and mechanism of action Biochem. J. 314,911-916(1996).
2. Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues J. Med. Chem. 30(2),254-263(1987).
15(S)-HETRE Preparation Products And Raw materials
Tag:15(S)-HETRE(92693-02-2) Related Product Information
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