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12(S)-HETrE

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12(S)-HETrE manufacturers

  • 12(S)-HETrE
  • 12(S)-HETrE pictures
  • $333.00
  • 2026-07-27
  • CAS:72710-10-2
  • Purity:
  • Supply Ability: 10g
12(S)-HETrE Basic information
Product Name:12(S)-HETrE
Synonyms:12(S)-HETrE;8,10,14-Eicosatrienoic acid, 12-hydroxy-, (8Z,10E,12S,14Z)-;12(S)-hydroxy-8(Z),10(E),14(Z)-eicosatrienoic acid;12(S)-HETrE(solution in ethanol)
CAS:72710-10-2
MF:C20H34O3
MW:322.48
EINECS:
Product Categories:
Mol File:72710-10-2.mol
12(S)-HETrE Structure
12(S)-HETrE Chemical Properties
Boiling point 487.413±33.00 °C(Press: 760.00 Torr)(predicted)
density 0.971±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility 0.1 M Na2CO3: 2 mg/ml; DMF: Miseble; DMSO: Miseble; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka4.772±0.10(predicted)
Safety Information
MSDS Information
12(S)-HETrE Usage And Synthesis
Description12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA).1 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.1
Uses12(S)-HETrE is a fatty acid metabolite that inhibits platelet aggregation. 12(S)-HETrE can be used in thrombosis-related research[1].
DefinitionChEBI: 12(S)-HETrE is a HETrE that is (8Z,10E,14Z)-icosatrienoic acid in which the hydroxy group is located at the 12(S)-posiiton. It has a role as a human xenobiotic metabolite. It is functionally related to an all-cis-icosa-8,11,14-trienoic acid. It is a conjugate acid of a 12(S)-HETrE(1-).
References1. Ikei, K.N., Yeung, J., Apopa, P.L., et al. Investigations of human platelet-type 12-lipoxygenase: Role of lipoxygenase products in platelet activation J. Lipid Res. 53(12),2546-2559(2012).
12(S)-HETrE Preparation Products And Raw materials
Tag:12(S)-HETrE(72710-10-2) Related Product Information
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