Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

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Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- Basic information
Product Name:Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-
Synonyms:Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-;VPC-70063;VPC70063,Anticancer,LNCaP,VPC 70063,inhibit,Myc-Max,UBE2C,Apoptosis,VPC-70063,c-Myc,PARP,AR-V7,Myc,Inhibitor,poly ADP ribose polymerase;1-benzyl-3-(3,5-bis(trifluoromethyl)phenyl)thiourea;VPC-70063, 10 mM in DMSO;N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(phenylmethyl)thiourea
CAS:13571-44-3
MF:C16H12F6N2S
MW:378.34
EINECS:
Product Categories:
Mol File:13571-44-3.mol
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- Structure
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- Chemical Properties
Melting point 151-153 °C
Boiling point 361.7±52.0 °C(Predicted)
density 1.417±0.06 g/cm3(Predicted)
pka11.80±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- Usage And Synthesis
DescriptionVPC-70063 is a Myc-Max inhibitor. VPC-70067 is a close analog of the previously identified Myc inhibitor 10058-F4. VPC-70063, of a chemically different scaffold, was the best performer in a panel of in vitro assays, and the forerunner for future hit-to-lead optimization efforts.
UsesVPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1].
References[1] Carabet LA, et al. Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer. Eur J Med Chem. 2018 Dec 5;160:108-119. DOI:10.1016/j.ejmech.2018.09.023
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- Preparation Products And Raw materials
Tag:Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-(13571-44-3) Related Product Information
1-Benzyl-3-phenyl-2-thiourea 1-phenyl-3-[4-(trifluoromethyl)phenyl]thiourea SULFATE-IONOPHORE I 1-[3,5-Bis(trifluoromethyl)phenyl]-3-(3-{3-[3,5-bis(trifluoromethyl)phenyl]thioureido}propyl)thiourea Thiourea,N-(2-hydroxyethyl)-N'-[3-(trifluoromethyl)phenyl]- Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-