2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]-

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2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]- manufacturers

  • Nurr1 agonist 2
  • Nurr1 agonist 2 pictures
  • $88.00
  • 2026-05-06
  • CAS:742058-34-0
  • Purity: 98.78%
  • Supply Ability: 10g
2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]- Basic information
Product Name:2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]-
Synonyms:2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]-;Nurr1 agonist 2;Nurr1agonist2|||Nurr1 agonist 2;5-[4-(Phenylmethoxy)phenyl]-2-thiophenecarboxylic acid
CAS:742058-34-0
MF:C18H14O3S
MW:310.37
EINECS:
Product Categories:
Mol File:742058-34-0.mol
2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]- Structure
2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]- Chemical Properties
Boiling point 519.2±50.0 °C(Predicted)
density 1.285±0.06 g/cm3(Predicted)
pka3.58±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]- Usage And Synthesis
UsesNurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC50: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a Kd value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression[1].
IC 50Nurr1/NR4A2
References[1] Ballarotto M, et al.De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J Med Chem. 2023 Jun 22;66(12):8170-8177. DOI:10.1021/acs.jmedchem.3c00485
2-Thiophenecarboxylic acid, 5-[4-(phenylmethoxy)phenyl]- Preparation Products And Raw materials
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