Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)-

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Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- Basic information
Product Name:Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)-
Synonyms:Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)-;WAY-640674;4-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(pyridin-3-yl)quinazoline;GCase modulator-1
CAS:796079-91-9
MF:C22H18N4
MW:338.41
EINECS:
Product Categories:
Mol File:796079-91-9.mol
Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- Structure
Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- Chemical Properties
Boiling point 490.0±45.0 °C(Predicted)
density 1.250±0.06 g/cm3(Predicted)
pka4.21±0.59(Predicted)
form Solid
color Off-white to yellow
Safety Information
MSDS Information
Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- Usage And Synthesis
UsesGCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM)[1].
References[1] Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230. DOI:10.1021/acs.jmedchem.8b01294
Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- Preparation Products And Raw materials
Tag:Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)-(796079-91-9) Related Product Information
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